City-state secession

In one of this blog's first posts, I said one possible long-term (100 year) future for the region would be for some countries to split apart with city-states taking a role.

To build on that: What is the first city to secede from its national government in Latin America or the Caribbean?

Here are a few criteria that I think would make it more likely. It would need to be a city that is not the capital or center of national politics. It would probably need to be a city with access to a coastline or at least a border, because being landlocked and surrounded would not be helpful. It would probably also need to be a city that has a different political, economic or social makeup from the capital or the national demographics.

In the context of modern Latin America, there is one city that fits all of those criteria: Guayaquil, Ecuador.  I could easily imagine a narrative that leads to it calling for separation from the national government in Quito in the coming decades.

There are a few other possibilities if you look 50 years out. There are some towns on the Caribbean coast of Central America, particularly in Honduras and Nicaragua, that could hypothetically call for full separation from the national government as they've been generally ignored throughout their history anyway. Rio or Sao Paulo or some cities in Northern Brazil (Recife?) could hypothetically make the attempt, though it's hard to imagine a political future today in which they do. I could also imagine an outlier scenario in which the Yucatan or Baja California areas of Mexico could make that attempt.

None of these scenarios are likely. I don't intend to predict that any of this will occur. However, whatever happens in the next 50 years to the borders of the region, it will be something that is considered an "unlikely" scenario today. Only by looking at the current map and imagining various possible futures can we really think about how Latin America can change 50 or 100 years out.